Background: Exhausting physical exercise increases lipid peroxidation and causes important muscle damages. The human body tries to mitigate these adverse effects by mobilizing its antioxidant defenses. Objectives: This study aims to investigate the effect of a maximal versus supra-maximal race sustained until exhaustion on lipid peroxidation, antioxidant activity and muscle-damage biomarkers in trained (i.e. long-distance and middle-distance runners) and sedentary subjects. Materials and Methods: The study has been carried out on 8 middle-distance runners (MDR), 9 long-distance runners (LDR), and 8 sedentary subjects (SS). Each subject has undergone two exhaustive running tests, the first one is an incremental event (VAMEVAL test), the second one is a constant supra-maximal intensity test (limited-time test). Blood samples were collected at rest and immediately after each test. Results: A significant increase in malondialdehyde (MDA) concentrations was observed in SS and MDR after the VAMEVAL test and in LDR after the Limited-Time test. A significant difference was also observed between LDR and the other two groups after the VAMEVAL test, and between LDR and MDR after the Limited-Time test. Significant modifications, notably, in myoglobin, CK, LDH, IL-6, TNF-a, and TAS were likewise noted but depending on the race-type and the sportive specialty. Conclusions: Maximal and supra-maximal races induce a significant increase in lipid peroxidation and cause non-negligible inflammation and muscle damage. These effects were relatively related to the physical exercise type and the sportive specialty.
© Copyright 2016 Asian Journal of Sports Medicine. Tehran University of Medical Sciences, Sports Medicine Research Center. Alle Rechte vorbehalten. / Übersetzt mit https://www.DeepL.com/Translator