Associations of nicotinamide N-methyltransferase gene single nucleotide polymorphisms with sport performance and relative maximal oxygen uptake

(Zusammenhang zwischen dem Nicotinamide N-Methyltransferase-Einzelnukleotidgenpolymorphismus und der sportlichen Leistung und der maximalen Sauerstoffaufnahme)

To observe the associations between single nucleotide polymorphisms (SNPs) of nicotinamide N-methyltransferase (NNMT) gene and sport performance and to analyse genotype associations of the associated SNPs with sport performance and relative maximal oxygen uptake ().<br><br>Participants w...ere selected from 685 Chinese Han male college students. The completion times of a 1000-m run and a 50-m run were used to reflect sport performance, respectively. Nineteen tagSNPs were genotyped with Polymerase chain reaction–ligase detection reaction. Relative was directly determined with a cardiopulmonary function analyser.<br><br>A significant association was found between rs2256292 and 1000-m run performance, but no significant association was found between any tagSNPs and 50-m run performance. The genotype associations of rs2256292 with 1000-m run performance and with relative were both significant under the recessive model (CC vs. CG + GG).<br><br>No tagSNP in NNMT is significantly associated with 50-m run performance but rs2256292 is significantly associated with 1000-m run performance. The genotype associations of rs2256292 with sport performance are significant under recessive model, and a higher relative may be the physiological reason for minor homozygote CC carriers being of the better 1000-m runners.
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Schlagworte: Genetik Sportphysiologie O2-Aufnahme maximal Langstreckenlauf Lauf Kurzstreckenlauf
Notationen: Biowissenschaften und Sportmedizin
Veröffentlicht in: Journal of Sports Sciences
Veröffentlicht: 2017
Jahrgang: 35
Heft: 22
Seiten: 2185-2190
Dokumentenarten: Artikel
Sprache: Englisch
Level: hoch