The -786 T/C polymorphism of the NOS3 gene is associated with elite performance in power sports
(Der 786 T/C-Polymorphismus des NOS3-Gens steht in Zusammenhang mit der Spitzenleistung in Kraftsportarten )
The NOS3 gene is a candidate to explain individual variations in health and exercise related phenotypes. We compared genotypic and allelic frequencies of the NOS3 -786 T/C polymorphism (rs2070744) in three groups of men of the same Caucasian (Spanish) descent: (i) elite endurance athletes (cyclists, runners; N = 100); (ii) elite power athletes (jumpers, throwers, sprinters; N = 53) and (iii) non-athletic controls (N = 100). The frequency of the TT genotype was significantly higher in power athletes (57%) than in the endurance (33%, P = 0.017) or control group (34%, P = 0.026). The frequency of the T allele was also higher in power sportsmen (71%) than in their endurance (55%, P = 0.003) and control referents (56%, P = 0.015). No differences were observed between control and endurance groups. In summary, the -786 T/C polymorphism of the NOS3 gene seems to be associated with elite performance in power-oriented athletic events (throwing, jumping, sprinting), with the T allele exerting a beneficial effect. The mechanism by which this allele variant might benefit power performance remains to be elucidated.
© Copyright 2009 European Journal of Applied Physiology. Springer. Alle Rechte vorbehalten.
Schlagworte: | Genetik Leistung Test Diagnostik Eignung Kraft Schnellkraft |
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Notationen: | Biowissenschaften und Sportmedizin Kraft-Schnellkraft-Sportarten |
DOI: | 10.1007/s00421-009-1166-7 |
Veröffentlicht in: | European Journal of Applied Physiology |
Veröffentlicht: |
2009
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Jahrgang: | 107 |
Heft: | 5 |
Seiten: | 565-569 |
Dokumentenarten: | Artikel |
Sprache: | Englisch |
Level: | hoch |